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Current Issue - July 2016, Volume 10, Issue No. 2

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

Influence of Soluble Fillers in Improving Porosity of Handmade Antibiotic-Impregnated Polymethyl Methacrylate (PMMA) Beads: An in-vitro Study


  1. Gogia JS, Meehan JP, Di Cesare PE, Jamali AA. Local antibiotic therapy in osteomyelitis. Semin Plast Surg. 2009; 23(2): 100-7.
  2. Dunne JN, Hill JC, McEfee P, Todd K, Kirkpatrick, Tunney MM, et al. In vitro study of the efficacy of acrylic bone cement
  3. loaded with supplementary amounts of gentamicin: Effect on mechanical properties, antibiotic release, and biofilm formation. Acta Orthop. 2007; 78(6): 774-85.
  4. Lewis G, Bhattaram A. Influence of a pre-blended antibiotic (gentamicin sulphate powder) on various mechanical, thermal, and physical properties of three acrylic bone cements. J Biomaterials Appl. 2006; 20: 377-408.
  5. Bistolfi A, Massaza G, Verne E, Masse A, Deledda D, Ferraris S, et al. Antibiotic-Loaded Cement in Orthopedic Surgery: A Review. J ISRN Orthopedics. 2011: 1-8.
  6. Siaw FY, Michael A, Jonathan S, Zhibing Z. Understanding the Mechanical Properties of Single Microparticle and Their Compaction Behaviour. J China Particuology. 2006; 4(1-4): 35-40.
  7. He L, Tjong SC. Low percolation threshold of grapheme/polymer composites prepared by solvothermal reduction of grapheme oxide in the polymer solution. Nanoscale Res Lett. 2013; 8(1): 132-9
  8. Mc Laren AC, Mc Laren SG, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of Daptomycin. J Clin Orthop. 2006; 451: 25-8.
  9. Chang YH, Tai CL, Hsu HY, Hsieh PH, Lee MS, Ueng WN, et al. Liquid antibiotics in bone cement. Bone Joint Res. 2014; 3: 246-51.
  10. Rasyid HN. Novel concepts in preparing handmade antibiotic-loaded polymethylmethacrylate beads for the treatment of chronic osteomyelitis [dissertation]. School of Electrical Engineering and Informatics, Institut Teknologi Bandung, 2008.
  11. Joosten U, Joist A, Gosheger G, Liljenqvist U, Brandt B, von Eiff C. Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis. Biomaterials. 2005; 26(25): 5251-8.
  12. Saberi AA. Recent advances in percolation theory and its application. J Physics. 2015; 578: 1-32.
  13. Cekmer O, Um S, Mench MW. Application of pat-percolation theory and Lattice-Boltzmann method to investigate structureproperty relationships in porous media. Int’l J of Heat and Mass Transfer. 2015; 86: 101-12.
  14. Samuel S, Mathew BS, Veeraraghavan B. In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cement. J Orthop Traumatol. 2012; 13: 131-6.
  15. Ariani A, Soegijoko S, Rasyid HN. In E. Halit, Webster J.G., Drug Delivery System in eMedicine and mHealth. In: The EMedicine, E-Health, M-Health, Telemedicine, and Telehealth Handbook. Vol I. CRC Press, Taylor & Francis Group, Boca Raton, London, New York: 2015; 342-4.
  16. Rasyid HN, van der Mei HC, Frijlink HW, Soegijoko S, van Horn JR, Busscher HJ, et al. Concepts for increasing gentamicin release from handmade bone cement beads. Acta Orthop. 2009; 80(5): 508-13.

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The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

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