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Current Issue - November 2016, Volume 10, Issue No. 3

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

Role of Local Infiltration of Tranexamic Acid in Reducing Blood Loss in Peritrochanteric Fracture Surgery in the Elderly Population


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  2. Yu W, Zhang X, Wu R, Zhu X, Hu J, Xu Y, Yi J, et al. The visible and hidden blood loss of Asia proximal femoral nail antirotation and dynamic hip screw in the treatment of intertrochanteric fractures of elderly high- risk patients: a retrospective comparative study with a minimum 3 years of follow-up. BMC Musculoskelet Disord. 2016; 17: 269.
  3. Zhang L, Su W, Zhao J. Risk factors of perioperative blood loss in elderly patients receiving proximal femur locking compression plate fixation for intertrochanteric fractures. Nan Fang Yi Ke Da Xue Xue Bao. 2015; 35(12): 1797-801.
  4. Echave M, Oyagüez I, Casado MA. Use of Floseal (R), a human gelatine-thrombin matrix sealant, in surgery: a systematic review. BMC Surg. 2014; 14: 111.
  5. Astermark J, Rocino A, Von Depka M, Van Den Berg HM, Gringeri A, Mantovani LG, et al. EHTSB: Current use of bypassing agents in Europe in the management of acute bleeds in patients with haemophilia and inhibitors. Haemophilia. 2007; 13: 38-45.
  6. Oremus K, Sostaric S, Trkulja V, Haspl M. Influence of tranexamic acid on postoperative autologous blood retransfusion in primary total hip and knee arthroplasty: a randomized controlled trial. Transfusion. 2014; 54(1): 31-41.
  7. Wind TC, Barfield WR, Moskal JT. The effect of tranexamic acid on blood loss and transfusion rate in primary total knee arthroplasty. J Arthroplasty. 2013; 28(7): 1080-3.
  8. Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escolano F. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion. 2008; 48(3): 519-25.
  9. Veien M, Sorensen JV, Madsen F, Juelsgaard P. Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand. 2002; 46(10): 1206-11.
  10. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br. 2001; 83(5): 702-5.
  11. Ho KM, Ismail H. Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care. 2003; 31(5): 529-37.
  12. Cheriyan T, Maier SP 2nd, Bianco K, Slobodyanyuk K, Rattenni RN, Lafage V, et al. Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J. 2015; 15(4): 752-61.
  13. Zhang F, Wang K, Li FN, Huang X, Li Q, Chen Z, et al. Effectiveness of tranexamic acid in reducing blood loss in spinal surgery: a meta-analysis.
  14. Wang M, Zheng XF, Jiang LS. Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis. PLoS One. 2015; 10(9).
  15. Zufferey PJ, Miquet M, Quenet S, Martin P, Adam P, Albaladejo P, et al. Tranexamic acid in hip fracture surgery: a randomized controlled trial. Br J Anaesth. 2010; 104(1): 23-30.
  16. Piggott RP, Leonard M. Is there a role for antifibrinolytics in pelvic and acetabular fracture surgery? Ir J Med Sci. 2016; 185(1):29-34.
  17. Xie B, Tian J, Zhou DP. Administration of Tranexamic acid reduces postoperative blood loss in Calcaneal fractures: A Randomized Control Trial. J Foot Ankle Surg. 2015; 54(6): 1106-10.
  18. Dakir A, Ramalingam B, Ebenezer V, Dhanavelu P. Efficacy of Tranexamic Acid in Reducing Blood Loss during Maxillofacial Trauma Surgery-A Pilot Study. J Clin Diagn Res. 2014; 8(5): ZC06-8.
  19. Jennings JD, Solarz MK, Haydel C. Application of Tranexamic Acid in Trauma and Orthopedic Surgery. Orthop Clin North Am. 2016; 47(1): 137-43.
  20. Wang H, Shen B, Zeng Y. Comparison of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a metaanalysis of randomized controlled and prospective cohort trials. Knee. 2014; 21(6): 987-93.
  21. Soni A, Saini R, Gulati A, Paul R, Bhatty S, Rajoli SR. Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty. J Arthroplasty. 2014; 29(8): 1525-7.
  22. Blanié A, Bellamy L, Rhayem Y, Flaujac C, Samama CM, Fontenay M, et al. Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow-up study. Thromb Res. 2013; 131(1): e6-e11.
  23. Drakos A, Raoulis V, Karatzios K, Doxariotis N, Kontogeorgakos V, Malizos K, et al. Efficacy of local administration of Tranexamic Acid for blood salvage in patients undergoing intertrochanteric fracture surgery. J Orthop Trauma. 2016; 30 (8): 409-14.

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The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

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