MOJ Header

Ahead of Print Issue - July 2021, Volume 15, Issue No. 2

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

Explaining Osteomyelitis and Prosthetic Joint Infections (PJI) in terms of Biofilm – A Review


  1. McConoughey SJ, Howlin R, Granger JF, Manring MM, Calhoun JH, Shirtliff M, et al. Biofilms in periprosthetic orthopedic infections. Future Microbiol. 2014; 9(8): 987-1007. doi: 10.2217/fmb.14.64
  2. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007; 22(3): 465-75. doi: 10.1359/jbmr.061113
  3. Sebastian S, Malhotra R, Sreenivas V, Kapil A, Chaudhry R, Dhawan B. Sonication of orthopaedic implants: A valuable technique for diagnosis of prosthetic joint infections. J Microbiol Methods. 2018; 146:51-4. doi: 10.1016/j.mimet.2018.01.015
  4. Hayden SC, Zhao G, Saha K, Phillips RL, Li X, Miranda OR, et al. Aggregation and interaction of cationic nanoparticles on bacterial surfaces. J Am Chem Soc. 2012; 134(16): 6920-3. doi:10.1021/ja301167y
  5. Sudhaharan S, Vemu L, Mamidi N, Chavali P. Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis. J Lab Physicians. 2018; 10(1): 21–5. doi:10.4103/jlp.jlp_14_17
  6. Van Acker H, Coenye T. The role of efflux and physiological adaptation in biofilm tolerance and resistance. J Biol Chem. 2016; 291(24): 12565-72. doi:10.1074/jbc.r115.707257
  7. Jones HC, Roth IL, Sanders WM 3rd. Electron microscopic study of a slime layer. J Bacteriol. 1969; 99(1): 316–25. doi: 10.1128/jb.99.1.316-325
  8. Maciuceanu B, Jiga LP, Nistor A, Patrascu J, Ionac M. Chronic osteomyelitis of long bones. Timisoara Med J. 2005; 55(1): 85-102.
  9. Allewell NM. Introduction to biofilms thematic minireview series. J Biol Chem. 2016; 291(24): 12527-8. doi: 10.1074/jbc.R116.734103
  10. Peterson DA. Confocal microscopy. In: Kompoliti K, Metman LV, editors. Encyclopedia of Movement Disorders. Oxford: Elsevier; 2010. p 250-2.
  11. García-Betancur JC, Goñi-Moreno A, Horger T, Schott M, Sharan M, Eikmeier J, et al. Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus. eLife. 2017; 6: e28023. doi: 10.7554/eLife.28023
  12. de Mesy Bentley KL, MacDonald A, Schwarz E, Oh I. Chronic osteomyelitis with Staphylococcus aureus deformation in submicron canaliculi of osteocytes. JBJS Case Connect. 2018; 8(1): e8. doi: 10.2106/JBJS.CC.17.00154
  13. McHenry MC, Alfidi RJ, Wilde AH, Hawk WA. Hematogenous osteomyelitis; a changing disease. Cleveland Clinic quarterly. 1975; 42(1): 125-53. doi: 10.3949/ccjm.42.1.125
  14. Decho AW, Gutierrez T. Microbial extracellular polymeric substances (EPSs) in ocean systems. Front Microbiol. 2017; 8: 922. doi: 10.3389/fmicb.2017.00922
  15. Boles BR, Horswill AR. Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog. 2008; 4(4): e1000052. doi: 10.1371/journal.ppat.1000052
  16. Li X, Robinson SM, Gupta A, Saha K, Jiang Z, Moyano DF, et al. Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano. 2014; 8(10): 10682-6. doi: 10.1021/nn5042625
  17. Pichiotino E, Schaller TM. Open Fractures. Medscape. overview#showall (accessed on 28 August 2020)
  18. Wang LS, Gupta A, Rotello VM. Nanomaterials for the treatment of bacterial biofilms. ACS Infect Dis. 2016; 2(1):3-4. doi: 10.1021/acsinfecdis.5b00116
  19. Donlan RM. Biofilms: microbial life on surfaces. Emerg Infect Dis. 2002; 8(9): 881-90. doi: 10.3201/eid0809.020063
  20. Brady RA, Leid JG, Calhoun JH, Costerton JW, Shirtliff ME. Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunol Med Microbiol. 2008; 52(1): 13-22. doi:10.1111/j.1574-695x.2007.00357.x
  21. Valentini M, Filloux A. Biofilms and cyclic di-GMP (c-di-GMP) signaling: Lessons from Pseudomonas aeruginosa and other bacteria. J Biol Chem. 2016; 291(24): 12547-55. doi:10.1074/jbc.r115.711507
  22. Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med. 1970; 282(4): 198-206. doi: 10.1056/nejm197001222820406
  23. Hall-Stoodley L, Costerton JW, Stoodley P. Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol. 2004; 2(2): 95-108. doi: 10.1038/nrmicro821
  24. Nie B, Long T, Ao H, Zhou J, Tang T, Yue B. Covalent immobilization of Enoxacin onto titanium implant surfaces for inhibiting multiple bacterial species infection and in vivo Methicillin-Resistant Staphylococcus aureus infection prophylaxis. Antimicrob Agents Chemother. 2017; 61(1): e01766-16. doi: 10.1128/AAC.01766-16
  25. Ren Z, Steinberg LM, Regan JM. Electricity production and microbial biofilm characterization in cellulose-fed microbial fuel cells. Water Sci Technol. 2008; 58(3): 617-22. doi: 10.2166/wst.2008.431

Abstract   |   Reference

MOJ footer

About Us

The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

Keep in Touch

creative-commons License